Recurrent Implantation Failure

Michael Slowey, MS, MD

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 0.75 CME

• Human reproduction is inefficient with the Implantation of the embryo into the endometrium requiring a normal embryo (genetically, metabolically, functionally), a morphologically normal uterus, a receptive endometrium, appropriate synchronization between the embryo and endometrium and the ability of the embryo to attach and invade the endometrium but not go too far. However, even under ideal conditions, implantation does not occur. We will review the basics of implantation, discuss some of the reasons for failure, suggest an evaluation paradigm and critically evaluate some of the treatments that have been proposed.

1. Demonstrate knowledge of the basic of human embryo implantation.

2. Define recurrent implantation failure.

3. Describe an evaluation of patients with recurrent implantation failure.

4. Be able to critically evaluate some of the treatments that have been proposed for the treatment of RIF.